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Intracellular ROS production <t>of</t> <t>CIP</t> (A) and <t>CMP</t> (B) in MN and PMN leukocytes. Data (means ± S.D.) were expressed as percent of values in control cells of three independent experiments. *** p < 0.001 vs. control.
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Intracellular ROS production <t>of</t> <t>CIP</t> (A) and <t>CMP</t> (B) in MN and PMN leukocytes. Data (means ± S.D.) were expressed as percent of values in control cells of three independent experiments. *** p < 0.001 vs. control.
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Image Search Results


Intracellular ROS production of CIP (A) and CMP (B) in MN and PMN leukocytes. Data (means ± S.D.) were expressed as percent of values in control cells of three independent experiments. *** p < 0.001 vs. control.

Journal: Frontiers in Pharmacology

Article Title: Evaluation of the protective effect of quercetin and luteolin against ciprofloxacin- and chloramphenicol-induced oxidative stress in blood cells and their impact on the microbiological activity

doi: 10.3389/fphar.2025.1626058

Figure Lengend Snippet: Intracellular ROS production of CIP (A) and CMP (B) in MN and PMN leukocytes. Data (means ± S.D.) were expressed as percent of values in control cells of three independent experiments. *** p < 0.001 vs. control.

Article Snippet: Interactions between flavonoids and antibiotics were evaluated as described previously ( ) by checkerboard assay on Mueller-Hinton broth following the indications of . Four strains have been evaluated: two sensitive strains to CIP and CMP ( S. aureus ATCC 29213 and E. coli ATCC 25922), and two clinical strains ( S. aureus resistant to CIP and E. coli resistant to CIP).

Techniques: Control

Dose–response curves for Q, LT, and vitamin C on intracellular ROS produced by 16 μg/mL CIP (A) and 10 μg/mL CMP (B) in PMN human leukocytes.

Journal: Frontiers in Pharmacology

Article Title: Evaluation of the protective effect of quercetin and luteolin against ciprofloxacin- and chloramphenicol-induced oxidative stress in blood cells and their impact on the microbiological activity

doi: 10.3389/fphar.2025.1626058

Figure Lengend Snippet: Dose–response curves for Q, LT, and vitamin C on intracellular ROS produced by 16 μg/mL CIP (A) and 10 μg/mL CMP (B) in PMN human leukocytes.

Article Snippet: Interactions between flavonoids and antibiotics were evaluated as described previously ( ) by checkerboard assay on Mueller-Hinton broth following the indications of . Four strains have been evaluated: two sensitive strains to CIP and CMP ( S. aureus ATCC 29213 and E. coli ATCC 25922), and two clinical strains ( S. aureus resistant to CIP and E. coli resistant to CIP).

Techniques: Produced

Effect of LT and Q on SOD enzyme activity in PMN human leukocytes exposed to CIP (A) and CMP (B) . Data (means ± S.D.) are expressed as SOD units per 10 6 cells of three independent experiments. * p < 0.05, ** p < 0.01, *** p < 0.001, statistical differences compared to control leukocytes; # p < 0.05, ## p < 0.01, ### p < 0.001, statistical differences compared to leukocytes treated with CIP or CMP.

Journal: Frontiers in Pharmacology

Article Title: Evaluation of the protective effect of quercetin and luteolin against ciprofloxacin- and chloramphenicol-induced oxidative stress in blood cells and their impact on the microbiological activity

doi: 10.3389/fphar.2025.1626058

Figure Lengend Snippet: Effect of LT and Q on SOD enzyme activity in PMN human leukocytes exposed to CIP (A) and CMP (B) . Data (means ± S.D.) are expressed as SOD units per 10 6 cells of three independent experiments. * p < 0.05, ** p < 0.01, *** p < 0.001, statistical differences compared to control leukocytes; # p < 0.05, ## p < 0.01, ### p < 0.001, statistical differences compared to leukocytes treated with CIP or CMP.

Article Snippet: Interactions between flavonoids and antibiotics were evaluated as described previously ( ) by checkerboard assay on Mueller-Hinton broth following the indications of . Four strains have been evaluated: two sensitive strains to CIP and CMP ( S. aureus ATCC 29213 and E. coli ATCC 25922), and two clinical strains ( S. aureus resistant to CIP and E. coli resistant to CIP).

Techniques: Activity Assay, Control

Effect of LT and Q on CAT enzyme activity in PMN human leukocytes exposed to CIP (A) and CMP (B) . Data (means ± S.D.) are expressed as CAT units per 10 6 cells of three independent experiments. * p < 0.05, ** p < 0.01, *** p < 0.001, statistical differences compared to control leukocytes; # p < 0.05, ## p < 0.01, ### p < 0.001, statistical differences compared to leukocytes treated with CIP or CMP.

Journal: Frontiers in Pharmacology

Article Title: Evaluation of the protective effect of quercetin and luteolin against ciprofloxacin- and chloramphenicol-induced oxidative stress in blood cells and their impact on the microbiological activity

doi: 10.3389/fphar.2025.1626058

Figure Lengend Snippet: Effect of LT and Q on CAT enzyme activity in PMN human leukocytes exposed to CIP (A) and CMP (B) . Data (means ± S.D.) are expressed as CAT units per 10 6 cells of three independent experiments. * p < 0.05, ** p < 0.01, *** p < 0.001, statistical differences compared to control leukocytes; # p < 0.05, ## p < 0.01, ### p < 0.001, statistical differences compared to leukocytes treated with CIP or CMP.

Article Snippet: Interactions between flavonoids and antibiotics were evaluated as described previously ( ) by checkerboard assay on Mueller-Hinton broth following the indications of . Four strains have been evaluated: two sensitive strains to CIP and CMP ( S. aureus ATCC 29213 and E. coli ATCC 25922), and two clinical strains ( S. aureus resistant to CIP and E. coli resistant to CIP).

Techniques: Activity Assay, Control

Effect of LT and Q on protein oxidation induced by CIP (A) and CMP (B) in PMN human leukocytes. Data (means ± S.D.) are expressed as µmol chloramine T per mg protein of three independent experiments. * p < 0.05, ** p < 0.01, *** p < 0.001, statistical differences compared to control leukocytes; # p < 0.05, ## p < 0.01, ### p < 0.001, statistical differences compared to leukocytes treated with CIP or CMP.

Journal: Frontiers in Pharmacology

Article Title: Evaluation of the protective effect of quercetin and luteolin against ciprofloxacin- and chloramphenicol-induced oxidative stress in blood cells and their impact on the microbiological activity

doi: 10.3389/fphar.2025.1626058

Figure Lengend Snippet: Effect of LT and Q on protein oxidation induced by CIP (A) and CMP (B) in PMN human leukocytes. Data (means ± S.D.) are expressed as µmol chloramine T per mg protein of three independent experiments. * p < 0.05, ** p < 0.01, *** p < 0.001, statistical differences compared to control leukocytes; # p < 0.05, ## p < 0.01, ### p < 0.001, statistical differences compared to leukocytes treated with CIP or CMP.

Article Snippet: Interactions between flavonoids and antibiotics were evaluated as described previously ( ) by checkerboard assay on Mueller-Hinton broth following the indications of . Four strains have been evaluated: two sensitive strains to CIP and CMP ( S. aureus ATCC 29213 and E. coli ATCC 25922), and two clinical strains ( S. aureus resistant to CIP and E. coli resistant to CIP).

Techniques: Control

Quercetin (Q) and chloramphenicol (CMP) interaction by checkerboard assay. (A) Escherichia coli clinical strain resistant to CIP. (B) Staphylococcus aureus clinical strain resistant to CIP. (C) Escherichia coli ATCC 25922. (D) Staphylococcus aureus ATCC 29213.

Journal: Frontiers in Pharmacology

Article Title: Evaluation of the protective effect of quercetin and luteolin against ciprofloxacin- and chloramphenicol-induced oxidative stress in blood cells and their impact on the microbiological activity

doi: 10.3389/fphar.2025.1626058

Figure Lengend Snippet: Quercetin (Q) and chloramphenicol (CMP) interaction by checkerboard assay. (A) Escherichia coli clinical strain resistant to CIP. (B) Staphylococcus aureus clinical strain resistant to CIP. (C) Escherichia coli ATCC 25922. (D) Staphylococcus aureus ATCC 29213.

Article Snippet: Interactions between flavonoids and antibiotics were evaluated as described previously ( ) by checkerboard assay on Mueller-Hinton broth following the indications of . Four strains have been evaluated: two sensitive strains to CIP and CMP ( S. aureus ATCC 29213 and E. coli ATCC 25922), and two clinical strains ( S. aureus resistant to CIP and E. coli resistant to CIP).

Techniques:

Luteolin (LT) and chloramphenicol (CMP) interaction by checkerboard assay. (A) Escherichia coli clinical strain resistant to CIP. (B) Staphylococcus aureus clinical strain resistant to CIP. (C) Escherichia coli ATCC 25922. (D) Staphylococcus aureus ATCC 29213.

Journal: Frontiers in Pharmacology

Article Title: Evaluation of the protective effect of quercetin and luteolin against ciprofloxacin- and chloramphenicol-induced oxidative stress in blood cells and their impact on the microbiological activity

doi: 10.3389/fphar.2025.1626058

Figure Lengend Snippet: Luteolin (LT) and chloramphenicol (CMP) interaction by checkerboard assay. (A) Escherichia coli clinical strain resistant to CIP. (B) Staphylococcus aureus clinical strain resistant to CIP. (C) Escherichia coli ATCC 25922. (D) Staphylococcus aureus ATCC 29213.

Article Snippet: Interactions between flavonoids and antibiotics were evaluated as described previously ( ) by checkerboard assay on Mueller-Hinton broth following the indications of . Four strains have been evaluated: two sensitive strains to CIP and CMP ( S. aureus ATCC 29213 and E. coli ATCC 25922), and two clinical strains ( S. aureus resistant to CIP and E. coli resistant to CIP).

Techniques: